EFFICACY OF TOPICAL NITROGLYCERIN AND TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION ON SURVIVAL OF RANDOM-PATTERN SKIN FLAPS IN RATS

• DOI: 10.1080/alp.37.1.10.13
• Publication Date: 2009-12-09T12:19:22Z
• Authors: Can Atalay; E. Arzu Koçkaya; Bahadir Çetin; Kemal Kismet; M. Turan Akay
• Keywords: Skin flap; Nitroglycerin (drug)

We compared the efficacy of topical nitroglycerin and transcutaneous electrical nerve stimulation (TENS) on survival random-pattern skin flaps in rats. Thirty Wistar albino rats were used a dorsal, cranially-based flap was raised. The divided into three groups 10 each. first group had only raised while second third given 5 mg or TENS for one hour day seven days. amount necrosis measured seventh postoperative day. mean area 726.2, 544.2, 150.0 mm 2 control, nitroglycerin, groups, respectively. percentage that necrosed 51.9, 38.9, 10.7 corresponding groups. significantly higher surviving than control (p 3 0.0001) = 0.002). TENS, with its negligible side-effects, could be reliable treatment. Clinically, it can easily postoperatively when become ischaemic, will tolerated well by patients.