REPRODUCTIVE TOXICITY OF THE PSORALENS

• DOI: 10.1080/pdp.22.3.247.258
• Publication Date: 2009-12-08T20:49:14Z
• Authors: Moussa M. Diawara...; Paul J. Kulkosky,...
• Keywords: Reproductive toxicity; Bergapten

The psoralens are naturally occurring secondary metabolites in plants, including many fruits and vegetables. Health risks have been associated with handling or ingesting psoralen-containing the use of synthetic photochemotherapy skin disorders. Our research has demonstrated that administration bergapten (5-methoxypsoralen) xanthotoxin (8-methoxypsoralen) diet female rats reduced birthrates, number implantation sites, pups, corpora lutea, full empty uterine weight, circulating estrogen levels a dose-dependent manner. Psoralens induced mRNAs liver enzymes CYP1A1 UGT1A6, suggesting enhanced metabolism estrogens by psoralen treatment may explain reproductive toxicity observed reduction ovarian follicular function ovulation. Rats also avoided repeated consumption flavored solution administration. findings indicate constitute novel group toxicants. Further examination safety their is warranted.