Topical Liposomal Gel of Tretinoin for the Treatment of Acne: Research and Clinical Implications

• DOI: 10.1081/pdt-100102029
• Publication Date: 2002-07-26T16:42:31Z
• Authors: Vandana B. Patel; Ambikanandan Misra; Yogesh S. Marfatia
• Keywords: Erythema

An attempt was made to pharmaceutically develop a topical liposomal tretinoin (TRE) gel and clinically evaluate the developed formulation for treatment of acne in patients. Liposomes TRE were prepared using lipid film hydration technique entrapment efficiency liposomes optimized 79.96%. The drug retention (Carbopol 934 base) studied at three storage conditions indicated maximum refrigeration temperature. For gel, reduced leakage observed as compared that all conditions. Diffusion studies plain suggested prolongation (3.4 times reduction flux value) diffusion almost two- fold increase skin after encapsulation drug. A comparative double-blind clinical study carried out on 30 patients over period 3 months, demonstrated significant enhancement (about 1.5-fold) efficacy. More remarkable improvement comedones, where mean percent lesions increased from 62.36% 94.17% gel. Erythema irritation associated with use considerably findings this investigation therefore underscore potential utility commercialization acne.