RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization

• DOI: 10.1083/jcb.202012001
• Publication Date: 2021-08-23T13:15:41Z
• Authors: Masashi Mori; Tatsuma Yao; Tappei Mishina; Hiromi Endoh; Masahito Tanaka; Nao Yonezawa; Yuta Shimamoto; Shigenobu Yonemura; Kazuo Yamagata; Tomoya S. Kitajima; Masahito Ikawa
• Keywords: Ran

Zygotes require two accurate sets of parental chromosomes, one each from the mother and father, to undergo normal embryogenesis. However, upon egg–sperm fusion in vertebrates, zygote has three sperm egg. The therefore eliminates set maternal chromosomes (but not paternal chromosomes) into polar body through meiosis, but how are protected meiosis been unclear. Here we report that RanGTP F-actin dynamics prevent proximity chromosomes. prevents localization Juno CD9, egg membrane proteins mediate fusion, at cell surface Following keeps away Disruption these mechanisms causes elimination during meiosis. This study reveals a novel critical mechanism aneuploidy zygotes.