The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans

• DOI: 10.1083/jcb.202212035
• Publication Date: 2023-11-27T14:22:01Z
• Authors: Ruoxi Wang; Jiaxiang Li; Yuqi Tian; Yating Sun; Yu Zhang; Mengfei Liu; Ruirui Zhang; Li Zhao; Qian Li; Xiaoqian Meng; Jun Zhou; Jinmin Gao
• Keywords: Synapsis; Bivalent (engine); Synaptonemal complex; Chromosomal crossover

During meiosis, cohesin and meiosis-specific proteins organize chromatin into an axis-loop architecture, coordinating homologous synapsis, recombination, ordered chromosome segregation. However, how the meiotic axis is assembled differentiated with progression remains elusive. Here, we explore dynamic recruitment of two long arms bivalent proteins, LAB-1 LAB-2, in Caenorhabditis elegans. LAB directly interact core HORMA complexes weak interactions contribute to their recruitment. phase separate vitro, this capacity promoted by complexes. early prophase, synapsis oppositely regulates enrichment proteins. After pachytene exit, switch from a reciprocal localization pattern colocalization pattern, normal altered mutants. We propose that senses differentiation, separation structures helps subdomain establishment accurate segregation chromosomes.