LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER

• DOI: 10.1084/jem.135.6.1406
• Publication Date: 2004-06-23T23:23:31Z
• Authors: Alvito P. Alvares; Susan Leigh; Jonathan Cohn; Attallah Kappas
• Keywords: Male; 0301 basic medicine; Aniline Compounds; Time Factors; Sulfhydryl Reagents; Hexobarbital; Environmental Exposure; Pigments, Biological; Mixed Function Oxygenases; Rats; 3. Good health; Lead Poisoning; 03 medical and health sciences; Morphinans; Depression, Chemical; Mercury Poisoning; Microsomes, Liver; Animals; Cytochromes; Environmental Pollution; Sleep

The rat liver mixed function oxidase system which is responsible for the metabolism of endogenous and exogenous compounds has been shown to be affected by lead and methyl mercury. Administration of these environmental pollutants to rats results in a decrease in cytochrome P-450 content and inhibition of in vitro N-demethylase and hydroxylase activities. The in vitro enzyme-inhibiting effects of the metals found pharmacological expression in the whole animal by prolongation of hexobarbital-induced sleeping times.