THE ABILITY OF BACTERIAL LIPOPOLYSACCHARIDE TO MODULATE THE INDUCTION OF UNRESPONSIVENESS TO A STATE OF IMMUNITY

• DOI: 10.1084/jem.138.6.1481
• Publication Date: 2004-06-23T23:23:31Z
• Authors: J. A. Louis; J. M. Chiller; W. O. Weigle
• Keywords: Immunogen; Priming (agriculture); Adoptive Cell Transfer

Studies were performed to define the cellular parameters involved in interference with induction of immunologic unresponsiveness human gamma globulin (HGG) by bacterial lipopolysaccharide (LPS). Mice which injected deaggregated HGG (tolerogen) and LPS did not become tolerant that antigen, but rather became primed a subsequent challenge immunogen. The ability prime tolerogen was also demonstrated an adoptive transfer system. temporal relationship between injection critical for priming occur. only mice HGG, resulted primary antibody response HGG. capacity interfere tolerance restricted B cells affect induce T cells. secondary found be T-cell independent. These observations are interpreted discussed from standpoint circumvent required cooperation modulate tolerogenic stimulus into immunogenic signal.