Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.

• DOI: 10.1084/jem.143.6.1391
• Publication Date: 2004-06-23T21:00:50Z
• Authors: H Cantor; F W Shen; E A Boyse
• Keywords: Priming (agriculture); Subclass

Cells of the Lyl subclass generate helper activity in both primary and secondary responses to sheep erythrocytes (SRBC). In contrast, after priming with SRBC, cells Ly-2+ subclasses, particular Ly23 cells, have suppressive activity. The degree Ly23-mediated suppression is directly proportional amount antigen (SRBC) used for priming. Suppression by specific, because from SRBC-primed animals do not suppress response horse erythrocytes, vice versa. Thus, cytotoxic specific suppressor functions are mediated T a subclass, provisionally designated TCS, which can be distinguished (TH), their Ly phenotypes. It remains determined whether killing functionally interrelated properties single or population comprises two subclasses whose surface phenotypes yet distinguishable immunogenetic criteria.