Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.

• DOI: 10.1084/jem.147.4.1116
• Publication Date: 2004-06-23T21:00:50Z
• Authors: H Cantor; L McVay-Boudreau; J Hugenberger; K Naidorf; F W Shen; R K Gershon
• Keywords: Adoptive Cell Transfer

We have shown that (a) purified T-helper cells induce of another T-cell set-, expressing the Ly123+Qa1+ surface phenotype, to exert potent suppressive activity, (b) this T-T interaction plays an important role in regulating vivo immune responses, and (c) represents barrier protocols intended augment status individuals by adoptive (or active) immunotherapy. Our results also indicate Ly123+ set mediating feedback suppression is sensitive both low doses cyclophosphamide removal thymus adult life. The importance normal, physiologic regulation system emphasized finding major deficit NZB mice (an inbred strain spontaneously develops autoimmune disorder) absence or malfunction responsible for inhibition.