Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen.

• DOI: 10.1084/jem.167.5.1572
• Publication Date: 2004-06-24T07:56:10Z
• Authors: L L Lanier; D W Buck; L Rhodes; A Ding; E Evans; C Barney; J H Phillips
• Keywords: Lymphokine-activated killer cell

IL-2 potentiates both growth and cytotoxic function of T lymphocytes NK cells. Resting peripheral blood cells can respond directly to rIL-2, without requirement for accessory or cofactors, enhanced cytotoxicity be measured within a few hours after exposure this lymphokine. In study, we describe an activation antigen, Leu-23, that is rapidly induced phosphorylated stimulation subset low buoyant density lymphocytes. Previously, it has been uncertain whether all only are responsive IL-2. Since 18 h IL-2, essentially express these findings indicate by The Leu-23 antigen disulfide-bonded homodimer, composed 24-kD protein subunits with two N-linked oligosaccharides. Appearance glycoprotein on dependent closely parallels IL-2-induced against NK-resistant solid tumor cell targets.