Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease.

• DOI: 10.1084/jem.175.1.293
• Publication Date: 2004-06-24T07:56:10Z
• Authors: P Desreumaux; A Janin; J F Colombel; L Prin; J Plumas; D Emilie; G Torpier; A Capron; M Capron
• Keywords: Intestinal mucosa

Interleukin 5 (IL-5), the major factor involved in eosinophil differentiation, is produced by T cells or mast cells. In present study, we found that eosinophils infiltrating mucosa of four patients with active coeliac disease also express IL-5 mRNA. No positive signal was obtained normal duodenum tissues and cell infiltrate from submitted to gluten restriction. The identification labeled mucosal as relied on their typical morphology. Moreover, highly purified blood three out eosinophilia were strongly antisense but not corresponding sense probe. Together, these results suggest have capacity synthesize IL-5, which could contribute paracrine interactions B and, autocrine fashion, locally participate, through binding receptor, differentiation activation. These data might implications only pathology other diseases associated infiltration.