Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris.

• DOI: 10.1084/jem.181.2.769
• Publication Date: 2004-06-24T07:56:10Z
• Authors: A J Curry; K J Else; F Jones; A Bancroft; R K Grencis; D W Dunne
• Keywords: Trichuris; Schistosoma; Trichuriasis

In murine models of Schistosoma mansoni infection, egg production is associated with a switch from T helper cell (Th)1- to Th2-type responses both schistosome-specific and unrelated antigens. Polyparasitism common in human populations within S. endemic areas. We have, therefore, examined whether coinfection could affect the outcome second parasitic through Th2 cytokine-dependent modifications host immune response. find that when mice susceptible infection gut nematode Trichuris muris are coinfected mansoni, they acquire capacity resolve T. thus demonstrating resistant phenotype. This ability expel Th2-associated cytokines, corresponding antibody isotypes, response The shows there no compartmentalization between spleen mesenteric lymph nodes, expulsion not caused by any changes intestine excretion schistosome eggs. influence infections may be important, only for pathogens areas, but also efficacy vaccines such