Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene.

• DOI: 10.1084/jem.181.2.787
• Publication Date: 2004-06-24T07:56:10Z
• Authors: H Martien van Santen; A Woolsey; P G Rickardt; L Van Kaer; E J Baas; A Berns; S Tonegawa; H L Ploegh
• Keywords: Beta-2 microglobulin; BETA (programming language); Antigen processing

Mice harboring a deletion of the gene encoding transporter associated with antigen presentation-1 (TAP1) are impaired in providing major histocompatibility complex (MHC) class I molecules peptides cytosolic origin and lack stable MHC cell surface expression. They consequently have strongly reduced number CD8+ T cells. To examine whether selection cells is dependent on TAP-dependent peptides, we partially restored expression TAP1-deficient mice by introduction human beta 2-microglobulin. We show that functional can be augmented vivo absence TAP1-dependent peptides.