LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.

• DOI: 10.1084/jem.183.4.1415
• Publication Date: 2004-06-24T07:56:10Z
• Authors: R Schmits; T M Kündig; D M Baker; G Shumaker; J J Simard; G Duncan; A Wakeham; A Shahinian; A van der Heiden; M F Bachmann; P S Ohashi; T W Mak; D D Hickstein
• Keywords: CTL*; CD11a; Priming (agriculture); Ex vivo; Cellular immunity

The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects vitro aggregation, proliferation mixed reactions, response to mitogen. Mutant mounted normal cytotoxic T cell (CTL) responses against systemic LCMV VSV infections showed ex vivo CTL function. However, LFA-1-deficient did not reject immunogenic tumors grafted into footpads demonstrate priming tumor-specific antigen. Thus deficiency causes a selective defect induction of peripheral immune whereas infection are normal.