Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

• DOI: 10.1084/jem.185.5.825
• Publication Date: 2002-07-26T16:49:30Z
• Authors: Lars Rogge; Luisella Barberis...; Mauro Biffi; Nadia Passini; David H. Presky; Ueli Gubler; Francesco Sinigaglia
• Keywords: Common gamma chain; T helper cell; BETA (programming language)

Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays crucial role in regulating interferon (IFN)-γ production the generation of IFN–γ–producing T helper 1 (Th1) cells. Here we show that IL-12 receptor (IL12R) β2 subunit, recently cloned binding signal transducing component IL-12R, is expressed on human Th1 but not Th2 clones induced during differentiation naive cells along pathway. type I II interferons induce expression IL-12R chain vitro cell after antigen triggering. The selective regulation subunit may help to understand basis Th1/Th2 provide therapeutic options for altering balance several immuno-pathological conditions such as autoimmune diseases allergies.