The HIV-1 Virion-associated Protein Vpr Is a Coactivator of the Human Glucocorticoid Receptor

• DOI: 10.1084/jem.189.1.51
• Publication Date: 2002-07-26T16:49:30Z
• Authors: Tomoshige Kino; Alexander Gragerov; Jeffrey B. Kopp; Roland H. Stauber; George N. Pavlakis; George P. Chrousos
• Keywords: CREB-binding protein; Hormone response element

The HIV-1 virion-associated accessory protein Vpr affects both viral replication and cellular transcription, proliferation, differentiation. We report that enhances the activity of glucocorticoids in lymphoid muscle-derived cell lines by interacting directly with glucocorticoid receptor general transcription factors, acting as a coactivator. contains signature motif LXXLL also present nuclear coactivators, such steroid coactivator 1 p300/CREB-binding protein, which mediates their interaction other hormone receptors. A mutant molecule disruption this lost its ability to influence glucocorticoid-responsive genes became dominant-negative inhibitor Vpr, possibly retaining factor–binding activities. may contribute increased tissue sensitivity absence hypercortisolism pathogenesis AIDS.