The Role of β7 Integrins in CD8 T Cell Trafficking During an Antiviral Immune Response

• DOI: 10.1084/jem.189.10.1631
• Publication Date: 2002-07-26T16:49:30Z
• Authors: Leo Lefrançois; Christina M. Parker; Sara Olson; Werner Muller; Norbert Wagner; Lynn Puddington
• Keywords: Intraepithelial lymphocyte

The requirement of β7 integrins for lymphocyte migration was examined during an ongoing immune response in vivo. Transgenic mice (OT-I) expressing ovalbumin-specific major histocompatibility complex class I–restricted T cell receptor antigen were rendered deficient expression all or only the αEβ7 integrin. To quantitate relative use vivo, equal numbers OT-I and OT-I-β7−/− OT-I-αE−/− lymph node (LN) cells adoptively transferred to normal mice. Although LN migrated mesenteric peripheral as well wild-type cells, required naive CD8 B Peyer's patch. After infection with a recombinant virus (vesicular stomatitis virus) encoding ovalbumin, became critical activated Naive did not enter lamina propria intestinal epithelium, majority small large mucosa, including integrin–mediated. integrin appeared play no role primary Furthermore, despite dramatic upregulation by after entry into long-term retention intraepithelial lymphocytes also independent.