An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

CD4-Positive T-Lymphocytes Inflammation Mice, Knockout 0301 basic medicine Mice, Inbred BALB C Colon Antibodies, Monoclonal Mice, SCID Th1 Cells Interleukin-10 3. Good health DNA-Binding Proteins Colonic Diseases Interferon-gamma Mice 03 medical and health sciences Transforming Growth Factor beta Animals Intestinal Mucosa Immunity, Mucosal Spleen
DOI: 10.1084/jem.190.7.995 Publication Date: 2002-07-26T16:48:33Z
ABSTRACT
A T helper cell type 1–mediated colitis develops in severe combined immunodeficient mice after transfer of CD45RBhigh CD4+ cells and can be prevented by cotransfer the CD45RBlow subset. The immune-suppressive activities population reversed vivo administration an anti-transforming growth factor β antibody. Here we show that interleukin (IL)-10 is essential mediator regulatory functions population. This isolated from IL-10–deficient (IL-10−/−) was unable to protect when transferred alone immune-deficient recipients induced colitis. Treatment with anti–murine IL-10 receptor monoclonal antibody abrogated inhibition mediated wild-type (WT) cells, suggesting necessary for effector function Inhibition WT not dependent on production progeny as were able inhibit IL-10−/− cells. These findings provide first clear evidence plays a nonredundant role functioning control inflammatory responses towards intestinal antigens.
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