Tumor Necrosis Factor Receptor–Associated Factor (Traf)2 Represses the T Helper Cell Type 2 Response through Interaction with Nfat-Interacting Protein (Nip45)

• DOI: 10.1084/jem.194.1.89
• Publication Date: 2002-07-26T16:48:54Z
• Authors: Rebecca Lieberson; Kerri A. Mowen; Kathryn D. McBride; Veronica Leautaud; Xiankui Zhang; Woong-Kyung Suh; Lin Wu; Laurie H. Glimcher
• Keywords: NFAT

Recently we have identified a novel protein NIP45 (nuclear factor of activated T cells [NFAT]-interacting protein) which substantially augments interleukin (IL)-4 gene transcription. The provision together with NFAT and the helper cell type 2 (Th2)-specific transcription c-Maf to normally refractory IL-4 production, such as B or Th1 clones, results in substantial secretion levels that approximate those produced by primary Th2 cells. In studies designed further our understanding activity, uncovered facet regulation. We present evidence members tumor necrosis receptor–associated (TRAF) family proteins, generally known function adapter proteins transduce signals from receptor superfamily, contribute repression this effect is mediated through their interaction NIP45.