CD8+ T Cell–mediated Injury In Vivo Progresses in the Absence of Effector T Cells

• DOI: 10.1084/jem.194.12.1835
• Publication Date: 2002-07-26T16:48:33Z
• Authors: Barbara A. Small; Sarah A. Dressel; Christopher W. La...; Donald R. Drake; Mark H. Stoler; Richard I. Enelow; Thomas J. Braciale
• Keywords: Proinflammatory cytokine; Adoptive Cell Transfer

Tissue injury is a common sequela of acute virus infection localized to specific organ such as the lung. an immediate consequence with lytic viruses. It can also result from direct destruction infected cells by effector CD8+ T lymphocytes and indirectly through action cell–derived proinflammatory cytokines recruited inflammatory on uninfected tissue. We have examined cell–mediated pulmonary in transgenic model which adoptively transferred, virus-specific cytotoxic (CTLs) produce lethal, progressive recipient mice expressing viral target transgene exclusively lungs. found that over 4–5 day course development lethal injury, CTLs, while necessary for induction are present only transiently (24–48 h) provide evidence antiviral cells, type II alveolar not immediately destroyed cells. Rather, after cell–target interaction, stimulated chemokine monocyte chemoattractant protein 1. These results reinforce concept that, vivo, cellular targets CTLs may participate directly tissue activating response interaction producing mediators without sustained vivo activation cell effectors.