Osteopontin Is Involved in the Initiation of Cutaneous Contact Hypersensitivity by Inducing Langerhans and Dendritic Cell Migration to Lymph Nodes

• DOI: 10.1084/jem.194.9.1219
• Publication Date: 2002-07-26T16:48:33Z
• Authors: J.M. Weiss; A.C. Renkl; C.S. Maier; M. Kimmig; L. Liaw; T. Ahrens; S. Kon; M. Maeda; H. Hotta; T. Uede; J.C. Simon
• Keywords: Osteopontin; Epidermis (zoology)

Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration Langerhans cells/dendritic cells (LCs/DCs) from skin draining lymph nodes. Characterizing OPN function for LC/DC we found upregulated expression in hapten sensitized and induces migration, initiates their emigration epidermis, LCs/DCs nodes by interacting with CD44 αv integrin. Furthermore, OPN-deficient mice have significantly reduced CHS response correlates an impaired ability attract In conclusion, important factor initiation guiding into lymphatic organs.