Sensory Adaptation in Naive Peripheral CD4 T Cells

• DOI: 10.1084/jem.194.9.1253
• Publication Date: 2002-07-26T16:48:33Z
• Authors: Katy Smith; Benedict Seddon; Marco A. Purbhoo; Rose Zamoyska; Amanda G. Fisher; Matthias Merkensc...
• Keywords: CD4-Positive T-Lymphocytes; POSITIVE SELECTION; Physiological; Immunology; SIGNAL-TRANSDUCTION; Research & Experimental Medicine; Antigens, CD5; CD5 Antigens; IMMUNOLOGY; NEGATIVE REGULATION; Major Histocompatibility Complex; Mice; 03 medical and health sciences; 0302 clinical medicine; Animals; THYMIC SELECTION; Adaptation; Antigens; IN-VIVO; Medical And Health Sciences; Science & Technology; Research & Experimental; H-2 Antigens; CLASS-II MOLECULES; HOMEOSTATIC PROLIFERATION; TCR SIGNALS; Adaptation, Physiological; CD5; MHC contact; Medicine, Research & Experimental; Haplotypes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MEDICINE, RESEARCH & EXPERIMENTAL; B-CELLS; Medicine; T cell receptor repertoire; T cell responsiveness; Life Sciences & Biomedicine; p56(lck); ANTIGEN RECEPTOR

T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca2+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.