CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent Manner

• DOI: 10.1084/jem.20030580
• Publication Date: 2003-11-03T22:23:02Z
• Authors: Santos Mañes; Emilia Mira; Ramón Colomer; Sagrario Montero; Luis M. Real; Concepción Góme...; Sonia Jiménez-Ba...; Alfredo Garzón; Rosa Ana Lacalle; Keith Harshman; Agustín Ruíz; Carlos Martínez-A.
• Keywords: Chemokine receptor CCR5; Tumor progression

Chemokines are implicated in tumor pathogenesis, although it is unclear whether they affect human cancer progression positively or negatively. We found that activation of the chemokine receptor CCR5 regulates p53 transcriptional activity breast cells through pertussis toxin-, JAK2-, and p38 mitogen-activated protein kinase-dependent mechanisms. blockade significantly enhanced proliferation xenografts from bearing wild-type p53, but did not a mutation. In parallel, data obtained primary clinical series showed disease-free survival was shorter individuals CCR5Delta32 allele than patients, only for those whose tumors expressed p53. These findings suggest influences p53-dependent manner.