Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria
Parity (physics)
DOI:
10.1084/jem.20041579
Publication Date:
2004-11-02T16:52:52Z
AUTHORS (12)
ABSTRACT
In Plasmodium falciparum-endemic areas, pregnancy-associated malaria (PAM) is an important health problem. The condition precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process mediated parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA). Parasites causing PAM express unique VSA types, VSAPAM, which can be serologically classified as sex specific parity dependent. It because men from malaria-endemic areas do not develop VSAPAM antibodies; it dependent women acquire anti-VSAPAM immunoglobulin (Ig) G a function parity. Previously, was shown that transcription var2csa up-regulated placental parasites selected for CSA binding. Here, we show following: (a) VAR2CSA expressed on CSA-selected IEs; (b) recognized endemic plasma sex-specific parity-dependent manner; (c) high anti-VAR2CSA IgG levels found pregnant both West East Africa; (d) with give birth markedly heavier babies have much lower risk delivering low weight children than levels.
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