Developmental regulation of Foxp3 expression during ontogeny

• DOI: 10.1084/jem.20050784
• Publication Date: 2005-10-03T19:42:46Z
• Authors: Jason D. Fontenot; James L. Dooley; Andrew G. Farr; Alexander Y. Rude...
• Keywords: Thymectomy; Thymocyte

Thymectomy of neonatal mice can result in the development autoimmune pathology. It has been proposed that thymic output regulatory T (T reg) cells is delayed during ontogeny and disease neonatally thymectomized caused by escape self-reactive before thymectomy without accompanying reg cells. However, kinetics cell production within thymus not assessed. We demonstrate Foxp3-expressing substantially relative to nonregulatory thymocytes ontogeny. Based on our data, we speculate induction Foxp3 developing and, thus, commitment lineage facilitated a signal largely associated with medulla.