FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

• DOI: 10.1084/jem.20060353
• Publication Date: 2006-06-27T00:52:23Z
• Authors: Han You; Marc Pellegrini; Katsuya Tsuchihara; Kazuo Yamamoto; Georg Hacker; Miriam Erlacher; Andreas Villunger; Tak W. Mak
• Keywords: Puma; Mediator

Puma is an essential mediator of p53-dependent and -independent apoptosis in vivo. In response to genotoxic stress, induced a manner. However, the transcription factor driving up-regulation p53-independent apoptotic stimuli has yet be identified. Here, we show that FOXO3a up-regulates expression cytokine or growth deprivation. Importantly, dysregulated Akt signaling lymphoid cells attenuated induction upon withdrawal. Our results suggest Puma, together with another BH3 only member, Bim, function as downstream targets mediate stress when PI3K/Akt down-regulated.