An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response
Mice, Knockout
0303 health sciences
MAP Kinase Signaling System
Receptors, IgE
Articles
Immunoglobulin E
In Vitro Techniques
Models, Biological
Cell Degranulation
Enzyme Activation
Mice
Phosphatidylinositol 3-Kinases
03 medical and health sciences
Animals
Cytokines
Guanine Nucleotide Exchange Factors
Mast Cells
Anaphylaxis
Signal Transduction
DOI:
10.1084/jem.20061598
Publication Date:
2006-12-27T01:23:56Z
AUTHORS (5)
ABSTRACT
Cross-linking of the FcεRI activates phosphatidyl inositol 3 kinase (PI3K) and mitogen-activated protein pathways. Previous studies demonstrate that Ras guanyl nucleotide-releasing (RasGRP)1 is essential in T cell receptor–mediated Ras-Erk activation. Here, we report RasGRP1 plays an important role FcεRI-mediated PI3K activation mast function. RasGRP1-deficient mice failed to mount anaphylactic allergic reactions. RasGRP1−/− cells had markedly reduced degranulation cytokine production. Although Erk was normal, diminished. Consequently, Akt, PIP3-dependent kinase, C δ defective. Expression a constitutively active form N-Ras could rescue defect Akt We further demonstrated were defective granule translocation, microtubule formation, RhoA Our results identified as regulator
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (51)
CITATIONS (58)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....