Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity

• DOI: 10.1084/jem.20061640
• Publication Date: 2006-12-05T01:34:00Z
• Authors: Carole Berruyer; Laurent Pouyet; Virginie Millet; Florent M. Martin; Aude LeGoffic; Alexandra Canonici; Stéphane Garcia; Claude Bagnis; Philippe Naquet; Franck Galland
• Keywords: Mediator; Inflammatory mediator

Colitis involves immune cell-mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here deficiency protects from colitis. This protection reversible by administration cystamine or bisphenol A diglycidyl ether, peroxisome proliferator-activated receptor (PPAR)gamma antagonist. We further demonstrate Vanin-1, antagonizing PPARgamma, licenses production inflammatory mediators intestinal cells. propose sensor stress exerts dominant control over innate responses in Thus, Vanin-1/pantetheinase might be new target for therapeutic intervention bowel disease.