Accelerated tumor growth in mice deficient in DNAM-1 receptor

• DOI: 10.1084/jem.20081611
• Publication Date: 2008-11-25T02:26:00Z
• Authors: Akiko Iguchi-Manaka; Hirayasu Kai; Yumi Yamashita; Kai Shibata; Satoko Tahara-Han...; Shin-ichiro Honda; Teruhito Yasui; Hitoshi Kikutani; Kazuko Shibuya; Akira Shibuya
• Keywords: dNaM; Methylcholanthrene; CTL*

Since the identification of ligands for human and mouse DNAM-1, emerging evidence has suggested that DNAM-1 plays an important role in T cell– natural killer (NK) cell–mediated recognition lysis tumor cells. However, it remains undetermined whether is involved immune surveillance vivo. We addressed this question by using DNAM-1–deficient mice. cytotoxic lymphocyte (CTL) NK cells showed significantly less activity against ligand-expressing tumors vitro than wild-type (WT) The methylcholanthrene (MCA)-induced fibrosarcoma cell line Meth A expressed ligand CD155, mice increased development mortality after transplantation Moreover, developed more papilloma response to chemical carcinogens MCA 7,12-dimethylbenz[a]anthracene (DMBA), respectively, did WT These results indicate development.