Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

• DOI: 10.1084/jem.20090219
• Publication Date: 2009-10-06T01:52:43Z
• Authors: David K. Finlay; Linda V. Sinclair; Carmen Feijoo; Caryll M. Waugh; Thijs J. Hagenbeek; Hergen Spits; Doreen A. Cantrell
• Keywords: Tensin

In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)–mediated phosphorylation and activation of protein B (PKB) is essential for the inactivation Foxo family transcription factors, also controls growth proliferation. The current study has characterized role PDK1 in pathology caused by deletion tumor suppressor phosphatase tensin homologue deleted on chromosome 10 (PTEN). shown to be lymphomagenesis PTEN progenitors. However, bypasses PDK1-controlled signaling pathways that determine thymocyte does have important functions PTEN-null thymocytes, notably control PKB–Foxo axis direct repertoire adhesion chemokine receptors expressed cells. results thus provide two novel insights concerning pathological loss lymphocytes. First, metabolic checkpoints Second, determines cohort cells, thereby controlling their migratory capacity.