Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation

• DOI: 10.1084/jem.20160062
• Publication Date: 2016-03-21T14:24:51Z
• Authors: Jakob Loschko; Heidi A. Schreiber; Gereon J. Rieke; Daria Esterházy; Matthew M. Meredith; Virginia A. Pedicord; Kai-Hui Yao; Silvia Caballero; Eric G. Pamer; Daniel Mucida; Michel C. Nussenz...
• Keywords: Homeostasis; Innate lymphoid cell

Conventional dendritic cells (cDCs) play an essential role in host immunity by initiating adaptive T cell responses and serving as innate immune sensors. Although both functions of cDCs are well documented, their relative importance maintaining homeostasis is poorly understood. To examine the significance cDC-initiated homeostasis, independent activities, we generated a cDC-specific Cre mouse crossed it to floxed MHC class II (MHCII) mouse. Absence MHCII on resulted chronic intestinal inflammation that was alleviated antibiotic treatment entirely averted under germ-free conditions. Uncoupling revealed insufficient maintain antigen presentation for mutualistic relationship between bacteria.