Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths

• DOI: 10.1084/jem.20161104
• Publication Date: 2017-05-15T14:10:12Z
• Authors: Victoria S. Pelly; Stephanie M. Coomes; Yashaswini Kannan; Manolis Gialitakis; Lewis J. Entwistle; Jimena Perez-Lloret; Stephanie Czieso; Isobel S. Okoye; Dominik Rückerl; Judith E. Allen; Frank Brombacher; Mark S. Wilson
• Keywords: Heligmosomoides polygyrus

Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion CD4+Foxp3+ regulatory (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between and effector can therefore determine outcome infection. redifferentiation into Th has been identified hyperinflammatory diseases. In this study, we asked whether ex–T Th2 develop contribute type-2 immunity. Using multigene reporter fate-reporter systems, demonstrate that a significant proportion derive from Foxp3+ after Heligmosomoides polygyrus infection airway allergy. Ex-Foxp3 exhibit characteristic functions provide immunity H. polygyrus. Through selective deletion Il4ra on cells, further IL-4 is required for development ex-Foxp3 cells. Collectively, our findings indicate converting could concomitantly enhance limit cell–mediated suppression.