PRDM16 suppresses HIF-targeted gene expression in kidney cancer
Kidney cancer
PRDM16
DOI:
10.1084/jem.20191005
Publication Date:
2020-04-06T17:18:56Z
AUTHORS (15)
ABSTRACT
Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing the transcription factor PRDM16 in renal cancer. We show that restoration RCC cells suppresses vivo tumor growth. RNaseq analysis reveals imparts a predominantly repressive effect on transcriptome including suppression encoding semaphorin 5B (SEMA5B). SEMA5B is HIF target highly expressed promotes Functional studies demonstrate PRDM16's properties, mediated by physical interaction with transcriptional corepressors C-terminal binding proteins (CtBP1/2), are required for both expression and Finally, we reconstitution mutant unable to bind CtBPs nullifies effects repression growth suppression. Collectively, our uncover novel basis which amplified kidney cancer new mechanism exerts its suppressive effects.
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