Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

• DOI: 10.1084/jem.20200866
• Publication Date: 2020-10-12T18:29:06Z
• Authors: Takeshi Inoue; Ryo Shinnakasu; Chie Kawai; Wataru Ise; Eiryo Kawakami; Nicolas Sax; Toshihiko Oki; Toshio Kitamura; Kazuo Yamashita; Hidehiro Fukuyama; Tomohiro Kurosaki
• Keywords: BCL6

A still unanswered question is what drives the small fraction of activated germinal center (GC) B cells to become long-lived quiescent memory cells. We found here that a population GC-derived CD38intBcl6hi/intEfnb1+ with lower mTORC1 activity favored cell fate. Constitutively high led defects in formation cells; conversely, decreasing resulted relative enrichment this memory-prone over recycling-prone one. Furthermore, had higher levels Bcl2 and surface BCR that, turn, contributed their survival development. also downregulation Bcl6 increased expression both BCR. Given positive correlation between strength T help activity, our data suggest model which weak from together provision an signal are key for GC adopt