Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer

• DOI: 10.1084/jem.20210564
• Publication Date: 2021-12-17T14:29:48Z
• Authors: Michela Masetti; Roberta Carriero; Federica Portale; Giulia Marelli; Nicolò Morina; Marta Pandini; Marta Iovino; Bianca Partini; Marco Erreni; Andrea Ponzetta; Elena Magrini; Piergiuseppe Colombo; Grazia Elefante; Federico Simone C...; Joke M.M. den Haan; Clelia Peano; Javier Cibella; Alberto Termanini; Paolo Kunderfranco; Jolanda Brummelman; Matthew Wai Heng ...; Massimo Lazzeri; Rodolfo Hurle; Paolo Casale; Enrico Lugli; Ronald A. DePinho; Subhankar Mukhopa...; Siamon Gordon; Diletta Di Mitri
• Keywords: Lipid Accumulation

Tumor-associated macrophages (TAMs) are correlated with the progression of prostatic adenocarcinoma (PCa). The mechanistic basis this correlation and therapeutic strategies to target TAMs in PCa remain poorly defined. Here, single-cell RNA sequencing was used profile transcriptional landscape human PCa, leading identification a subset characterized by dysregulation pathways associated lipid metabolism. This correlates positively shorter disease-free survival is an accumulation lipids that dependent on Marco. Mechanistically, cancer cell–derived IL-1β enhances Marco expression macrophages, reciprocally, cell migration promoted CCL6 released lipid-loaded TAMs. Moreover, administration high-fat diet tumor-bearing mice raises abundance Finally, targeting blockade hinders tumor growth invasiveness improves efficacy chemotherapy models pointing combinatorial may influence patient outcomes.