Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Infectious disease and host defense
AUTOIMMUNITY
[SDV]Life Sciences [q-bio]
:aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos [COMPUESTOS QUÍMICOS Y DROGAS]
Innate immunity and inflammation
Pneumònia
Autoimmunity
Autoanticossos
Infectious disease (medical specialty)
FOS: Health sciences
COVID-19 (Malaltia)
DISEASE
Coronavirus Disease 2019
Basic medicine
Autoantibody
INFECTION
Medicine and Health Sciences
:virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]
CANDIDIASIS
Disease
Child
Internal medicine
Genetics and Pathogenesis of Type 1 Diabetes
Patient
Candidiasis
Gastroenterology
Life Sciences
:Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]
Odds ratio
Infectious Diseases
COVID-19 pneumonia, anti-IFN-α, autoantibodies
:Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies [CHEMICALS AND DRUGS]
Anticytokine Autoantibodies
Interferon Type I
Medicine
Interferon
Infection
Infants
Thymoma
SARS-Cov-2
:enfermedades respiratorias::enfermedades pulmonares::neumonía [ENFERMEDADES]
Immunology
ANTICYTOKINE AUTOANTIBODIES
:personas::Grupos de Edad::niño [DENOMINACIONES DE GRUPOS]
IMMUNITY
Coronavirus Disease 2019 Research
PATIENT
:Respiratory Tract Diseases::Lung Diseases::Pneumonia [DISEASES]
Antibodies
Article
Biochemistry, Genetics and Molecular Biology
Virology
Health Sciences
Genetics
Immunodeficiency
Humans
320505 Enfermedades infecciosas
Human Interferon
HUMAN INTERFERON
Antibody
Autoantibodies
FOS: Clinical medicine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immunity
Biology and Life Sciences
Health sciences
COVID-19
Interferon-alpha
Pneumonia
:Persons::Age Groups::Child [NAMED GROUPS]
Neutralizing antibody
Coronavirus disease 2019 (COVID-19)
FOS: Biological sciences
THYMOMA
ANTIBODIES
32 Ciencias médicas
DOI:
10.1084/jem.20231353
Publication Date:
2024-01-04T19:45:34Z
AUTHORS (303)
ABSTRACT
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2.
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