Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons.

• DOI: 10.1085/jgp.84.6.861
• Publication Date: 2004-05-13T23:16:46Z
• Authors: P Ruben; S Thompson
• Keywords: Hyperpolarization; Time constant

Recovery from K current inactivation was studied in molluscan neurons using two-microelectrode and internal perfusion voltage clamps. Experiments were designed to study the voltage-dependent delayed outward (IK) without contamination other currents. The amount of recovery rate increase dramatically when membrane potential is made more negative. time course at resting potential, -40 mV, well fit by a single exponential with constant 24.5 s (n = 7). At negative voltages, best sum two exponentials constants -90 mV 1.7 9.8 In unclamped cells, short hyperpolarization can cause rapid that results shortening action duration. We conclude there are inactivated states channel for both dependent. discussed terms multistate model gating developed R. N. Aldrich (1981, Biophys. J., 36:519-532).