Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes

• DOI: 10.1086/321005
• Publication Date: 2002-07-26T14:26:39Z
• Authors: Chloe L. Thio; David L. Thomas; James J. Goedert; David Vlahov; Kenrad E. Nelson; Margaret W. Hilga...; Stephen J. O'Brien; Peter Karacki; Darlene Marti; Jacquie Astemborski; Mary Carrington
• Keywords: Hepatitis C

A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other associations varied cohort, molecular HLA typing was performed on 200 HCV 374 matched persistently infected subjects. weakly combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53–0.97) but stronger black In white subjects, DRB1*0101 (OR, 0.32; CI, 0.17–0.60) its DQB1*0501 haplotype, whereas persistence DRB1*0301 2.36; 1.23–4.52) DQB1*0201 haplotype. These results support a role for alleles the immune response underscore importance of studying genetic diverse cohort