Longitudinal Study of Cervical Squamous Intraepithelial Lesions in Human Immunodeficiency Virus (HIV)–Seropositive and At‐Risk HIV‐Seronegative Women

• DOI: 10.1086/375783
• Publication Date: 2003-08-04T15:15:47Z
• Authors: Paula Schuman; Suzanne E. Ohmit; Robert S. Klein; Ann Duerr; Susan Cu‐Uvin; Denise J. Jamieson; Jean Anderson; Keerti V. Shah
• Keywords: Adult; Vaginal Smears; Adolescent; Uterine Cervical Neoplasms; HIV Infections; Middle Aged; Viral Load; Survival Analysis; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Risk Factors; Antiretroviral Therapy, Highly Active; Humans; Female; Longitudinal Studies; Neoplasms, Squamous Cell

We examined incidence and correlates of progression regression abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV)-seropositive 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive 34 (9%) had incident SILs detected by Pap test; 47 (7%) developed high-grade lesions. The was 11.5 cases among 2.6 per 100 person-years observation (rate ratio, 4.5; 95% confidence interval, 3.1–6.4; P<.001). Risk likelihood were increased with CD4+ lymphocyte counts <500 cells/mm3 papillomavirus (HPV) infection, risk-ordering from low-to high-risk HPV type. SIL less likely higher HIV loads. No beneficial effect highly active antiretroviral therapy demonstrated.