A Programmable Prompting Device Improves Adherence to Highly Active Antiretroviral Therapy in HIV-Infected Subjects with Memory Impairment

• DOI: 10.1086/432877
• Publication Date: 2005-08-19T14:07:41Z
• Authors: A. S. A. Andrade; H. F. McGruder; A. W. Wu; S. A. Celano; R. L. Skolasky; O. A. Selnes; I.-C. Huang; J. C. McArthur
• Keywords: Memory Impairment

Background. Patients cite "forgetting" as a reason for nonadherence to highly active antiretroviral therapy (HAART). We measured the effect of memory-prompting device on adherence HAART in memory-intact and memory-impaired human immunodeficiency virus (HIV)-infected subjects.Methods. The study was prospective, randomized, controlled trial involving 64 HIV-infected adults. intervention Disease Management Assistance System (DMAS) device, combined with monthly counseling. Control subjects received only DMAS programmed regimen data provide verbal reminders at dosing times. Adherence 24 weeks using electronic drug exposure monitor (eDEM) caps.Results. A total 58 completed 24-week period; 28 were naive (12 users 16 control subjects). Mean scores did not differ significantly between (80%) (65%). Post hoc analysis 31 (14 17 subjects) revealed higher rates among (77%), compared (57%) (P=.001). However, showed that improved (83%), (77%) (P=.25). At week twelve, 38% 14% had an undetectable plasma HIV RNA load (P=.014), 24, 34% (P=.49). CD4(+) cell counts arms. Virological immunological responses related use subjects.Conclusion. prompting but subjects.