Persistent Symptomless Human Metapneumovirus Infection in Hematopoietic Stem Cell Transplant Recipients

• DOI: 10.1086/505881
• Publication Date: 2006-07-25T11:22:50Z
• Authors: Maurizia Debiaggi; Filippo Canducci; Michela Sampaolo; Maria Chiara Mari...; Maurizio Parea; Cristina Terulla; Anna Amelia Colombo; Emilio Paolo Ales...; Letizia Zenone Br...; Milena Arghittu; Antonio Goglio; Roberta Migliavacca; Egidio Romero; Massimo Clementi
• Keywords: Metapneumovirus

Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most them and confirmed by virus isolation. etiology also evaluated during the same period samples pediatric with acute diseases (ARDs). Sequence analysis HSCT recipients genotype A strong interhost similarity; this pattern differs that observed ARDs. The data indicate may frequently develop symptomless infection.