Interferon (IFN)–γ–Inducible Protein–10: Association with Histological Results, Viral Kinetics, and Outcome during Treatment with Pegylated IFN‐α2a and Ribavirin for Chronic Hepatitis C Virus Infection

• DOI: 10.1086/507307
• Publication Date: 2006-09-05T17:36:50Z
• Authors: Ana I. Romero; Martin Lagging; Johan Westin; Amar P. Dhillon; Lynn B. Dustin; Jean‐Michel Pawlo...; Avidan U. Neumann; Carlo Ferrari; Gabriele Missale; Bart L. Haagmans; Solko W. Schalm; Stefan Zeuzem; Francesco Negro; Elke Verheij‐Hart; Kristoffer Hellst...
• Keywords: Pegylated interferon; Hepatitis C; Univariate analysis

We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4.Plasma IP-10 was monitored before, during, after pegylated IFN- alpha 2a ribavirin 265 HCV-infected patients.In univariate analyses, a low baseline level significantly associated load, rapid response (RVR), sustained (SVR), body mass index <25 kg/m2, less-pronounced fibrosis, inflammation, steatosis (for HCV other than 3). When the results of analyses were included multivariate plasma level, genotype 2 or 3 infection independent predictors an RVR SVR. levels decreased 6 weeks into remained By contrast, rebounded who had detectable RNA completion treatment. Using cutoff 150 600 pg/mL for predicting SVR 1 yielded specificity sensitivity 81% 95%, respectively.Baseline are predictive to