Pathogens in Early-Onset and Late-Onset Intensive Care Unit–Acquired Pneumonia

• DOI: 10.1086/511702
• Publication Date: 2007-03-21T10:20:37Z
• Authors: K. M. C. Verhamme; W. De Coster; L. De Roo; H. De Beenhouwer; G. Nollet; J. Verbeke; I. Demeyer; P. Jordens
• Keywords: Stenotrophomonas maltophilia; Hospital-acquired pneumonia; Bacteremia

To compare the type of pathogens isolated from patients with early-onset intensive care unit (ICU)-acquired pneumonia those late-onset ICU-acquired and to study risk factors for isolation that are potentially resistant multiple drugs.Prospective cohort study.Patients admitted ICU a 677-bed, university-affiliated teaching hospital in Belgium during 1997-2002.ICU-acquired was defined as case occurred 2 days or more after admission combination positive results radiologic analysis, clinical signs symptoms, culture result. All cases were categorized either early onset (within 7 admission) late (7 admission), without previous antibiotic treatment, corresponding analyzed. Risk drugs (ie, Pseudomonas aeruginosa, Serratia marcescens, Enterobacter species, Morganella morganii, methicillin-resistant Staphylococcus aureus, Citrobacter Acinetobacter Burkholderia extended-spectrum beta -lactamase-producing pathogens, Stenotrophomonas maltophilia) analyzed using logistic regression analysis.A total 4,200 stayed at days, 298 whom developed pneumonia, an overall incidence 13 (95% confidence interval [CI], 11-14 cases) per 1,000 ICU-days. Pathogens 52% pneumonia. these greater age receipt prophylaxis (adjusted odds ratio [aOR], 4.6 [95% CI, 1.6-13.0]) therapy (aOR, 8.2 2.8-23.8]). The length stay weaker pathogens.Pathogens Previous use (both prophylactic therapeutic) is main factor pathogens.