Genotypes of the Mannan‐Binding Lectin Gene and Susceptibility to Visceral Leishmaniasis and Clinical Complications

• DOI: 10.1086/512683
• Publication Date: 2007-03-15T17:40:18Z
• Authors: Diego Peres Alonso; Afonso Flávio B. ...; Paulo Eduardo M. ...; Isabel K. F. de M...; Maria do Socorro ...; Fernando Aécio de...; Antonio Roberto R...; Dorcas Lamounier ...; Guilherme L. Werneck; Teresinha J. C. F...; Maria José S. Soares; Carlos Henrique N...
• Keywords: Lectin pathway; Mannan; Leishmania chagasi

Visceral leishmaniasis (VL) is almost always lethal if not treated, but most infections with the causative agents are clinically silent. Mannan-binding lectin (MBL), an opsonin, a candidate molecule for modifying progression to VL because it may enhance infection intracellular pathogens. Mutations in MBL2 gene decrease levels of MBL and protect against development VL. This case-control study examines genotypes individuals presenting different outcomes Leishmania chagasi.Genotypes serum were determined uninfected control subjects (n=76) asymptomatic (n=90) or (n=69).Genotypes resulting high more frequent (odds ratio [OR], 2.5 [95% confidence interval [CI], 1.3-5.0]; P=.006) among than those even (OR, 3.97 CI, 1.10-14.38]; P=.043) cases clinical complications uneventful courses. Serum higher (P=.011) .Genotypes predict risk developing L. chagasi.