Myeloid Differentiation Primary Response Gene 88 Is Required for the Resolution of Otitis Media

• DOI: 10.1086/593213
• Publication Date: 2008-11-05T14:35:39Z
• Authors: Michelle Hernandez; Anke Leichtle; Kwang Pak; Joerg Ebmeyer; Sara Euteneuer; Marygorret Obonyo; Donald G. Guiney; Nicholas J. Webster; David H. Broide; Allen F. Ryan; Stephen I. Wasserman
• Keywords: Mice, Knockout; 0303 health sciences; Haemophilus Infections; Ear, Middle; Haemophilus influenzae; Anti-Bacterial Agents; 3. Good health; Mice, Inbred C57BL; Mice; Otitis Media; 03 medical and health sciences; Gene Expression Regulation; Myeloid Differentiation Factor 88; Animals; Gentamicins

Signaling defects in the Toll-like receptor (TLR) pathway, such as interleukin-1 receptor–associated kinase 4 deficiency, highlight the prominence of TLR signaling in the defense against bacterial disease. Because myeloid differentiation primary response gene 88 (MyD88) can transduce signals from almost all TLRs, we studied its role in otitis media (OM), the most common upper respiratory tract bacterial infectious disease in young children.