Incidence, Seasonality, Age Distribution, and Mortality of Pneumococcal Meningitis in Burkina Faso and Togo

• DOI: 10.1086/596498
• Publication Date: 2009-02-03T18:25:51Z
• Authors: Yves Traore; Tsidi Agbeko Tameklo; Berthe‐Marie Njan...; Mathilde Lourd; Seydou Yaro; Dominique Niamba; Aly Drabo; Judith E. Mueller; Jean‐Louis Koeck; Bradford D. Gessner
• Keywords: Case fatality rate

Streptococcus pneumoniae causes a substantial proportion of meningitis cases in the African belt; however, few reports exist to quantify its burden and characteristics. We conducted population-based sentinel hospital surveillance acute bacterial among persons all ages Burkina Faso Togo 2002–2006. S. other organisms were identified by culture, polymerase chain reaction, or detection antigen cerebrospinal fluid (CSF). Information was collected on 2843 patients with suspected meningitis. CSF specimens from 2689 (95%) patients; these 2689, 463 (17%) had identified, 234 (9%) Haemophilus influenzae type b 400 (15%) Neisseria meningitidis identified. Of meningitis, 99 (21%) aged <1 year, 71 1–4 years, 95 5–14 189 (41%) ⩾15 years (age unknown for 9 [2%]). In Faso, annual incidence rate pneumococcal 14 per 100,000 persons, rates 77, 33, 10, 11 <5 respectively. The case-fatality ratio 47% (range age groups, 44%–52%), 53% deaths occurred those >5 years. an epidemic pattern similar that N. 48 isolates tested serotype, 18 children years; 18, 3 each serotypes 1, 2, 5, 5 (28%) serotype 6A. 7-, 10-, 13-valent conjugate vaccines would cover 6%, 39%, 67% 30 ⩾5 (60%) whereas no constituted >10%. 7%, 70%, 77% serotypes. Epidemic belt countries is common, affects highly lethal. On basis modest number limited area includes only cases, 7-valent vaccine might have short-term role. By contrast, proposed 10- most To better inform policy, continued expanded essential document associated pneumonia, changes distribution across time, impact after introduction.