Male Circumcision Decreases Acquisition and Increases Clearance of High‐Risk Human Papillomavirus in HIV‐Negative Men: A Randomized Trial in Rakai, Uganda

• DOI: 10.1086/652184
• Publication Date: 2010-04-07T01:31:39Z
• Authors: Ronald H. Gray; David Serwadda; Xiangrong Kong; Frederick Makumbi; Godfrey Kigozi; Patti E. Gravitt; Stephen Watya; Fred Nalugoda; Victor Ssempijja; Aaron A. R. Tobian; Noah Kiwanuka; Lawrence H. Moulton; Nelson K. Sewankambo; Steven J. Reynolds; Thomas C. Quinn; Boaz Iga; Oliver Laeyendecker; Amy E. Oliver; Maria J. Wawer
• Keywords: Rate ratio; Cumulative incidence

Uncircumcised human immunodeficiency virus (HIV)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed (control 399 subjects). Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and 6, 12, 24 months. Incident high-risk (HR-HPV) estimated in who acquired a new HR-HPV genotype. clearance determined with prior genotype-specific infections. Rate ratios (RRs) 95% confidence intervals (CIs) of acquisition Poisson multiple regression.Enrollment characteristics comparable between study groups. incidence 19.7 cases per 100 person-years (PYs) the intervention arm (70 355.8 PYs) 29.4 PYs (125 424.8 control (RR, 0.67; CI, 0.51-0.89; P = .006). The infections 6.7 14.8 0.45; 0.28-0.73), but there no significant effect on single 0.89; 0.60-1.30). lower for all genotypes demographic/behavioral subgroups. preexisting 215.8 (205 95 159.1 (255 160.25 (adjusted RR, 1.39; 1.17-1.64).Male reduces increases HIV-uninfected men.ClinicalTrials.gov identifier: NCT00425984 .