Bimetallic nanoparticles: towards selective analysis of phosphorylated compounds by surface-enhanced Raman spectroscopy.

• DOI: 10.1088/1361-6528/adc583
• Publication Date: 2025-04-07
• Authors: Vladimír Jonas; Jiri Volanek; Jan Přikryl; Anna Týčová
• Keywords: Bimetallic strip; Surface-Enhanced Raman Spectroscopy

The selective detection of phosphorylated molecules is crucial for various biochemical and analytical applications, yet remains challenging due to their weak Raman signals limited interactions with conventional SERS substrates. This study presents a novel synthesis strategy bimetallic Ag/FexOynanocomposites ambition the improved sensitivity selectivity compounds. Our approach successfully integrates alkaline precipitation iron salts reduction silver cations, overcoming inherent incompatibility these processes produce stable colloid. resulting nanocomposites feature an architecture that ensures direct analyte interaction both components: oxides selectively capture molecules, while provides plasmonic enhancement signal. findings highlight critical role silver/iron interface in governing sensitivity. work represents significant step toward more effective SERS-based strategies, potential applications real-time analysis using flow-based systems, such as online monitoring after separation techniques medical fields.