Activity of Interferons Alpha, Beta, and Gamma Against Human Immunodeficiency Virus Replication In Vitro

• DOI: 10.1089/aid.1987.3.125
• Publication Date: 2009-03-16T14:27:22Z
• Authors: KEVAN L. HARTSHORN; DAVID NEUMEYER; MARKUS W. VOGT; ROBERT T. SCHOOLEY; MARTIN S. HIRSCH
• Keywords: Monocyte; Alpha (finance); Interferon alfa; BETA (programming language); U937 cell

The antiviral activities of various interferon preparations against human immunodeficiency virus (HIV) were evaluated in vitro. Recombinant inferferon alpha-A, and beta interferons leukocyte-derived alpha show similar concentration-dependent activity. lymphocyte-derived gamma minimal activity HIV replication normal peripheral blood mononuclear cells, but definite the H9 lymphocytic U937 monocyte-macrophage cell lines.