Cell Surface Phenotypic Changes Induced in H9 T Cells Chronically Infected with HTLV Type I or HIV Type 1 or Coinfected with the Two Viruses

• DOI: 10.1089/aid.1995.11.145
• Publication Date: 2009-03-16T19:34:36Z
• Authors: NELLY NORAZ; BERNARD VERRIER; CHRISTOPHE FRAISIER; CLAUDE DESGRANGES
• Keywords: 0301 basic medicine; 0303 health sciences; T-Lymphocytes; Cell Membrane; HIV Infections; HTLV-I Infections; Cell Line; Immunophenotyping; 3. Good health; 03 medical and health sciences; Antigens, CD; HLA Antigens; HIV-1; Humans; Cell Adhesion Molecules

To investigate whether HTLV-I infection, HIV-1 or infection of HTLV-I-infected cells affect the expression cellular surface molecules, an T cell line derived from H9 was established (H36). uninfected infected with were then HIV-1. We have compared density different markers on these three lines. These consist cell-specific antigens (CD2, CD3, CD4, and CD8), activated (CD25 CD71), major histocompatibility complex (MHC) (class I II), adhesion molecules (LFA-1 ICAM-1). The experiments reported in this article show that chronic modulate several immunologically important antigens. nature extent lymphoid phenotypic modulation depend infecting virus. Furthermore, interact each other coinfected cells.